How a Chemist Needs Computer Science, Biology, and Engineering to Push the Limits of Modern Mass Spectrometry
Neil Kelleher
An emergent "Top Down" approach to proteome analysis will be described. It combines informatics with ultra-high performance mass spectrometry to enable efficient characterization of biological events that change the mass of protein molecules from that predicted by a genome sequence. Top Down holds promise for improved diagnostics and a deeper understanding of the signaling and regulatory "codes" eukaryotic cells use that are written in the language of post-translational modification.
Neil L. Kelleher
Assistant Professor of Chemistry
The University of Illinois at Urbana-Champaign
Professor Kelleher received a B.S. and B.A. from Pacific Lutheran U. in 1992, a Fulbright Fellowship the following year, and a Ph.D. from Cornell U. in 1997. After a NIH Postdoctoral Fellowship at Harvard Medical School with Chris Walsh, Kelleher joined the faculty at UIUC in 1999 as a bioanalytical chemist.

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